From: The pharmacokinetics of the interstitial space in humans
Species | Solute | Reference | Organ | VI | Comments |
---|---|---|---|---|---|
Rat | EDTA | sk. mus. | .081–091 | Renal ligature-sampled 30 minutes after death. | |
 |  |  | skin | .55–.73 |  |
 |  |  | tendon | .83 |  |
 |  |  | intestine | .28–.32 |  |
 |  | [66] | sk. mus | .12 | Renal ligature-samples from live rat. |
 |  |  | skin | .63 |  |
 |  | [67]1 | sk. mus. | .075 | Constant infusion. Measured time course of tissue uptake. |
 |  |  | skin | .52 |  |
 |  |  | intestine | .15–.25 | Muscle, stomach and intestine equilibrated in <40 minutes. |
 |  |  | stomach | .23 |  |
 |  |  | adipose | .49 |  |
 |  |  | liver | .34 |  |
 |  |  | lung | .2 |  |
 |  |  | brain | ≈ 0 |  |
 |  | [50] | skin | .61 | Renal ligature – divided skin into dermis and sub-cutaneous samples. |
 |  |  |    dermis | .67 |  |
 |  |  |    subcutis | .51 |  |
 |  | [68]1 | sk. mus | .15 | Constant infusion. Volume increased with time for skin and colon. Range indicates volume at 60 to 120 minutes |
 |  |  | skin | .44–.63 |  |
 |  |  | sm. intestine | .29 |  |
 |  |  | colon | .3–.41 |  |
 |  |  | adipose | 1.0 |  |
 | Sulfate | [69]1 | skin | .65 | Nephrectomized |
 |  |  | muscle | .26 |  |
 | Mannitol |  | skin | .66 |  |
 |  |  | muscle | .26 |  |
 | Sulfate | [70]1,2 | muscle | .12 | Nephrectomized |
 | Inulin | [9] | sk. mus. | .12 | Constant infusion. |
 |  |  | skin | .3 |  |
 |  |  | intestine | .12 |  |
 |  |  | liver | .2 |  |
 |  |  | lung | .27 |  |
 |  | [71]1 | sk. mus. | .1 | Constant infusion. Tissue uptake corresponds to capillary PS ≈ 0.6 ml/min/100 gm |
Rabbit | EDTA | [72] | sk. mus | .077 | Renal ligature. |
 |  |  | skin | .42 |  |
 | EDTA | [73]1,2 | sk. mus. | .10 | Renal ligature. Measured time course of tissue uptake. |
 |  |  | heart | .25 |  |
 | Sucrose |  | sk. mus. | .11 | Equilibrated in < 30 minutes. |
 |  |  | heart | .25 |  |
 | Inulin |  | sk. mus. | .1 |  |
 |  |  | heart | .24 |  |
 |  | [74] | sk. mus. | .09 | Renal ligature. Determined time constant T≈ 9 min. |
 |  |  | heart | .28 |    T ≈ 1 min. |
 |  |  | intestine | .2 |    T ≈ 1.5 min |
 |  |  | ear | .5 |    T ≈ 12 min |
Cat | EDTA | [75] | sk. mus. | .13 | Renal ligature. |
 |  |  | skin | .88 |  |
Dog | EDTA | [76] | sk. mus. | .16 | Renal ligature. |
 |  |  | skin | .78 |  |
 | Sulfate | [70]1,2 | muscle | .20 | Constant infusion. Equilibration time <30 minutes. |
 | Sucrose | [49]1 | sk. mus. | .23 | Constant infusion. Cannulated prepopliteal lymphatic and measured lymph sucrose |
 |  |  | skin | .53 |  |
 |  |  | tendon | .67 |  |
 | Thiosulfate | [51]2 | muscle | .13 | Renal ligature. Equilibration time < 180 min. |
 |  |  | skin | .77 | Equilibration time < 180 min |
 |  |  | tendon | .75 | Equilibration time ≥ 360 min. |
 | Inulin |  | muscle | .1 | Equilibration time < 180 min. |
 |  |  | skin | .48 | Equilibration time < 180 min |
 |  |  | tendon | .26 | Equilibration time ≥ 360 min. |
Man | Inulin1,2 | [77] | sk. mus. | .08–.11 | Bolus plus constant infusion. Tissue biopsy after 20 – 120 minutes. |