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Table 4 Interstitial volume (VI) – fraction of total extravascular water

From: The pharmacokinetics of the interstitial space in humans

Species Solute Reference Organ VI Comments
Rat EDTA [35, 64, 65] sk. mus. .081–091 Renal ligature-sampled 30 minutes after death.
    skin .55–.73  
    tendon .83  
    intestine .28–.32  
   [66] sk. mus .12 Renal ligature-samples from live rat.
    skin .63  
   [67]1 sk. mus. .075 Constant infusion. Measured time course of tissue uptake.
    skin .52  
    intestine .15–.25 Muscle, stomach and intestine equilibrated in <40 minutes.
    stomach .23  
    adipose .49  
    liver .34  
    lung .2  
    brain ≈ 0  
   [50] skin .61 Renal ligature – divided skin into dermis and sub-cutaneous samples.
       dermis .67  
       subcutis .51  
   [68]1 sk. mus .15 Constant infusion. Volume increased with time for skin and colon. Range indicates volume at 60 to 120 minutes
    skin .44–.63  
    sm. intestine .29  
    colon .3–.41  
    adipose 1.0  
  Sulfate [69]1 skin .65 Nephrectomized
    muscle .26  
  Mannitol   skin .66  
    muscle .26  
  Sulfate [70]1,2 muscle .12 Nephrectomized
  Inulin [9] sk. mus. .12 Constant infusion.
    skin .3  
    intestine .12  
    liver .2  
    lung .27  
   [71]1 sk. mus. .1 Constant infusion. Tissue uptake corresponds to capillary PS ≈ 0.6 ml/min/100 gm
Rabbit EDTA [72] sk. mus .077 Renal ligature.
    skin .42  
  EDTA [73]1,2 sk. mus. .10 Renal ligature. Measured time course of tissue uptake.
    heart .25  
  Sucrose   sk. mus. .11 Equilibrated in < 30 minutes.
    heart .25  
  Inulin   sk. mus. .1  
    heart .24  
   [74] sk. mus. .09 Renal ligature. Determined time constant T≈ 9 min.
    heart .28    T ≈ 1 min.
    intestine .2    T ≈ 1.5 min
    ear .5    T ≈ 12 min
Cat EDTA [75] sk. mus. .13 Renal ligature.
    skin .88  
Dog EDTA [76] sk. mus. .16 Renal ligature.
    skin .78  
  Sulfate [70]1,2 muscle .20 Constant infusion. Equilibration time <30 minutes.
  Sucrose [49]1 sk. mus. .23 Constant infusion. Cannulated prepopliteal lymphatic and measured lymph sucrose
    skin .53  
    tendon .67  
  Thiosulfate [51]2 muscle .13 Renal ligature. Equilibration time < 180 min.
    skin .77 Equilibration time < 180 min
    tendon .75 Equilibration time ≥ 360 min.
  Inulin   muscle .1 Equilibration time < 180 min.
    skin .48 Equilibration time < 180 min
    tendon .26 Equilibration time ≥ 360 min.
Man Inulin1,2 [77] sk. mus. .08–.11 Bolus plus constant infusion. Tissue biopsy after 20 – 120 minutes.
  1. 1Assumed total organ water (ml/100 gm) of: skeletal muscle, 75; heart, 78; skin, 60; subcutaneous tendon/ear, 60; stomach, 75; intestine, 73; adipose, 18.3; liver, 70; lung, 79 [35, 78]. 2Assumed plasma volume (ml/100 gm) of: skeletal muscle, 0.4; heart muscle, 2.0; skin 0.6 [64, 78].