Table 2 Equilibrium Volume of Distribution in Humans relative to body weight (VEQ) for selected solutes.
From: The pharmacokinetics of the interstitial space in humans
Solute | Reference | Fast time constant (minutes) | Slow time constant (minutes) | VEQ (liters/Kg) | Comments |
|---|---|---|---|---|---|
Amoxicillin | [46] | 9.8 | 909 | 0.26 | N = 4, 53 Kg, 45 years Renal failure: Clearance < 10 ml/min/1.73 m2 |
Morphine-6-glucuronide | [47] | 23 | 2083 | 0.24 | N = 6, 73.7 Kg, 48.7 years Renal Failure: Ave. clearance = 10 ml/min |
Inulin | [44] | NA | NA | 0.15 | N = 3, Constant infusion. Normal Males, ages 21–29. |
Sucrose | [45] | NA | NA | 0.159 | N = 3, Constant infusion. |
Inulin | Â | NA | NA | 0.162 | Â |