Skip to main content

Advertisement

Table 2 Equilibrium Volume of Distribution in Humans relative to body weight (VEQ) for selected solutes.

From: The pharmacokinetics of the interstitial space in humans

Solute Reference Fast time constant (minutes) Slow time constant (minutes) VEQ (liters/Kg) Comments
Amoxicillin [46] 9.8 909 0.26 N = 4, 53 Kg, 45 years Renal failure: Clearance < 10 ml/min/1.73 m2
Morphine-6-glucuronide [47] 23 2083 0.24 N = 6, 73.7 Kg, 48.7 years Renal Failure: Ave. clearance = 10 ml/min
Inulin [44] NA NA 0.15 N = 3, Constant infusion. Normal Males, ages 21–29.
Sucrose [45] NA NA 0.159 N = 3, Constant infusion.
Inulin   NA NA 0.162