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Figure 12 | BMC Clinical Pharmacology

Figure 12

From: The pharmacokinetics of the interstitial space in humans

Figure 12

Comparison of PBPK linear (left) or semi-log (right) plots of model predictions and experimental data for dicloxacillin from Lofgren et. al. [63]. The top row is the optimal fit for the case of a capillary permeability limitation (fclear [muscle] = 0.25, PSmuscle = 11 ml/min/100 gm, average error = 12%. The bottom row is the best fit for the flow limited case (fclear = 1, average error = 18%).

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