Figure 11
From: The pharmacokinetics of the interstitial space in humans
Comparison of PBPK linear (left) or semi-log (right) plots of model predictions and experimental data for flucloxacillin from Wise et. al.[29]. The top row is the optimal fit for the case of a capillary permeability limitation (fclear [muscle] = 0.344, PSmuscle = 7.0 ml/min/100 gm, average error = 6.4%). The bottom row is the best fit for the flow limited case (fclear = 1, average error = 11%).