Figure 10

Comparison of PBPK linear (left) or semi-log (right) plots of model predictions and experimental data for ceforanide from Pfeffer et. al. [32]. The top row is the optimal fit for the case of a capillary permeability limitation (fclear [muscle] = 0.518, PS_muscle = 5 ml/min/100 gm, average error = 4.3%). The bottom row is the best fit for the flow limited case (fclear = 1, average error = 8.6%).