Figure 2

"Simple" PBPK model with exact data sampled at high resolution. Accuracy of 2-exponential bolus input function determined using model venous concentration data generated using the "simple" PBPK organ model. The data was sampled (black squares) at the "high resolutions" time points (2.5, 5, 10, 15, 20, 25, 30, 60, 90, 120, 180, 300, 480 and 720 minutes). The left hand column shows the results for the case where a 30-second constant infusion IV infusion was used. The right hand column results are for a 10-minute constant IV infusion. The first 3 columns compare the model venous concentration (black) with the concentration determined using the bolus input function (red). The first row is for short times, the second for long times and the third is a semi-log plot for all times. The last row compares the deconvolution intestinal input rate (black) with the model input rate (green).