Table 5 Urinary excretion of codeine and metabolites after administration of 100 mg codeine phosphate (n = 12).
From: Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers
Ae [% of dose] | codeine + placebo mean (95% CI) | codeine + diclofenac mean (95% CI) | p level |
|---|---|---|---|
codeine | 3.74 (3.33–4.15) | 3.89 (3.10–4.68) | n.s. |
C-6-G | 62.2 (57.0–67.5) | 64.7 (60.7–68.7) | n.s. |
norcodeine | 1.76 (1.35–2.18) | 1.86 (1.36–2.36) | n.s. |
norcodeine-glucuronide | 3.87 (3.01–4.73) | 4.01 (3.02–5.00) | n.s. |
morphine | 0.22 (0.13–0.32) | 0.23 (0.14–0.33) | n.s. |
M-3-G | 4.40 (2.81–5.99) | 4.66 (3.10–6.22) | n.s. |
M-6-G | 1.21 (0.77–1.64) | 1.31 (0.83–1.78) | n.s. |
normorphine | 1.56 (1.91–1.93) | 1.73 (1.34–2.11) | n.s. |
normorphine-glucuronide | 2.30 (1.80–2.79) | 2.50 (1.99–3.01) | n.s. |