Table 4 Renal clearances of codeine and metabilites after administration of 100 mg codeine phosphate (n = 12).
From: Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers
Cl ren [ml min-1] | codeine + placebo mean (95% CI) | codeine + diclofenac mean (95% CI) | p level |
|---|---|---|---|
codeine | 66.5 (54.6–78.3) | 64.2 (53.6–74.9) | n.s. |
C-6-G | 88.6 (76.4–101) | 86.6 (78.6–94.5) | n.s. |
norcodeine | 220 (187–253) | 233 (208–259) | n.s. |
morphine | 117 (72.4–162) | 114 (83.6–144) | n.s. |
M-3-G | 88.2 (76.1–100) | 86.2 (77.1–95.4) | n.s. |
M-6-G | 122 (108–136) | 114 (101–127) | n.s. |
normorphine | 123 (106–141) | 133 (115–152) | n.s. |