Table 3 Partial metabolic clearances of codeine and morphine after administration of 100 mg codeine phosphate (n = 12).
From: Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers
Clmet [ml min-1] | codeine + placebo mean (95% CI) | codeine + diclofenac mean (95% CI) | p level |
|---|---|---|---|
codeine → C-6-G | 1134 (882–1385) | 1104 (928–1279) | n.s. |
codeine → morphine | 174 (118–230) | 176 (126–226) | n.s. |
codeine → norcodeine | 102 (69.1–136) | 97.1 (76.2–118) | n.s. |
morphine → M-3-G | 2631 (1227–4036) | 2550 (1527–3573) | n.s. |
morphine → M-6-G | 702 (362–1042) | 692 (446–938) | n.s. |
morphine → normorphine | 3090 (431–5749) | 2600 (1456–3744) | n.s. |