From: Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers
codeine + placebo mean (95% CI) | codeine + diclofenac mean (95% CI) | p level | |
---|---|---|---|
tmax codeine [h] | 0.69 (0.51–0.87) | 0.71 (0.51–0.91) | n.s. |
Cmax codeine [pmol/ml] | 764 (602–924) | 821 (663–980) | n.s. |
t1/2 codeine [h] | 3.37 (3.16–3.59) | 3.43 (3.24–3.62) | n.s. |
tmax C-6-G [h] | 1.13 (0.89–1.35) | 1.10 (0.87–1.34) | n.s. |
Cmax C-6-G [pmol/ml] | 5263 (4738–5788) | 5621 (5167–6074) | n.s. |
t1/2 C-6-G [h] | 3.54 (3.39–3.68) | 3.54 (3.36–3.73) | n.s. |
tmax morphine [h] | 0.63 (0.45–0.80) | 0.67 (0.53–0.81) | n.s. |
Cmax morphine [pmol/ml] | 22.4 (12.3–32.5) | 24.3 (13.7–35.0) | n.s. |
t 1/2 morphine [h] | 8.78 (5.97–11.59) | 8.54 (6.74–10.61) | n.s. |
tmax M-6-G [h] | 1.5 (1.37–1.64) | 1.35 (1.06–1.65) | n.s. |
Cmax M-6-G [pmol/ml] | 63.4 (38.7–88.1) | 68.8 (41.2–96.5) | n.s. |
t1/2M-6-G [h] | 7.77 (7.40–8.13) | 8.10 (7.57–8.63) | n.s. |