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Table 1 Time to attain peak serum concentrations (tmax) and terminal half-life of codeine and its metabolites (n = 12).

From: Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers

 

codeine + placebo mean (95% CI)

codeine + diclofenac mean (95% CI)

p level

tmax codeine [h]

0.69 (0.51–0.87)

0.71 (0.51–0.91)

n.s.

Cmax codeine [pmol/ml]

764 (602–924)

821 (663–980)

n.s.

t1/2 codeine [h]

3.37 (3.16–3.59)

3.43 (3.24–3.62)

n.s.

tmax C-6-G [h]

1.13 (0.89–1.35)

1.10 (0.87–1.34)

n.s.

Cmax C-6-G [pmol/ml]

5263 (4738–5788)

5621 (5167–6074)

n.s.

t1/2 C-6-G [h]

3.54 (3.39–3.68)

3.54 (3.36–3.73)

n.s.

tmax morphine [h]

0.63 (0.45–0.80)

0.67 (0.53–0.81)

n.s.

Cmax morphine [pmol/ml]

22.4 (12.3–32.5)

24.3 (13.7–35.0)

n.s.

t 1/2 morphine [h]

8.78 (5.97–11.59)

8.54 (6.74–10.61)

n.s.

tmax M-6-G [h]

1.5 (1.37–1.64)

1.35 (1.06–1.65)

n.s.

Cmax M-6-G [pmol/ml]

63.4 (38.7–88.1)

68.8 (41.2–96.5)

n.s.

t1/2M-6-G [h]

7.77 (7.40–8.13)

8.10 (7.57–8.63)

n.s.