Table 2 Levonorgestrel Single- and Multiple-dose Pharmacokinetics: Comparison of Mean Pharmacokinetic Parameters Across Treatments
Single Dose | Multiple Dose | ||||
|---|---|---|---|---|---|
LS Geometric Mean | Comparison to OC alone: Ratio (90% CI) | LS Geometric Mean | Comparison to OC alone: Ratio (90% CI) | ||
AUC (pg·h/mL) | OC alone | 55698.79 | - | 72974.62 | - |
1 h before exenatide | 53530.64 | 0.96 (0.90, 1.03) | 72952.67 | 1.00 (0.92, 1.09) | |
0.5 h after exenatide | 60591.89 | 1.09 (1.01, 1.17) | 76344.29 | 1.05 (0.96, 1.14) | |
C max (pg/mL) | OC alone | 3882.56 | - | 6598.95 | - |
1 h before exenatide | 4061.86 | 1.05 (0.94, 1.16) | 6657.22 | 1.01 (0.92, 1.10) | |
0.5 h after exenatide | 2284.25 | 0.59 (0.53, 0.65) | 4800.68 | 0.73 (0.67, 0.79) | |
24-h concentration (pg/mL) | OC alone | 600.88 | - | 2136.51 | - |
1 h before exenatide | 571.47 | 0.95 (0.89, 1.02) | 2173.05 | 1.02 (0.93, 1.11) | |
0.5 h after exenatide | 691.10 | 1.15 (1.07, 1.23) | 2367.68 | 1.11 (1.01, 1.21) | |
T max median (range) (h) | OC alone | - | 1.00 (0.50-2.07) | - | - |
1 h before exenatide | - | 0.92 (0.50-1.50) | - | - | |
0.5 h after exenatide | - | 4.75 (3.00-6.02) | - | - | |
t 1/2 geometric mean (range) (h) | OC alone | - | 33.6 (20.0-78.5) | - | - |
1 h before exenatide | - | 32.1 (19.8-55.7) | - | - | |
0.5 h after exenatide | - | 32.6 (17.9-72.4) | - | - | |