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Table 2 Levonorgestrel Single- and Multiple-dose Pharmacokinetics: Comparison of Mean Pharmacokinetic Parameters Across Treatments

From: Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial

   Single Dose Multiple Dose
   LS Geometric Mean Comparison to OC alone: Ratio (90% CI) LS Geometric Mean Comparison to OC alone: Ratio (90% CI)
AUC (pg·h/mL) OC alone 55698.79 - 72974.62 -
  1 h before exenatide 53530.64 0.96 (0.90, 1.03) 72952.67 1.00 (0.92, 1.09)
  0.5 h after exenatide 60591.89 1.09 (1.01, 1.17) 76344.29 1.05 (0.96, 1.14)
C max (pg/mL) OC alone 3882.56 - 6598.95 -
  1 h before exenatide 4061.86 1.05 (0.94, 1.16) 6657.22 1.01 (0.92, 1.10)
  0.5 h after exenatide 2284.25 0.59 (0.53, 0.65) 4800.68 0.73 (0.67, 0.79)
24-h concentration (pg/mL) OC alone 600.88 - 2136.51 -
  1 h before exenatide 571.47 0.95 (0.89, 1.02) 2173.05 1.02 (0.93, 1.11)
  0.5 h after exenatide 691.10 1.15 (1.07, 1.23) 2367.68 1.11 (1.01, 1.21)
T max median (range) (h) OC alone - 1.00 (0.50-2.07) - -
  1 h before exenatide - 0.92 (0.50-1.50) - -
  0.5 h after exenatide - 4.75 (3.00-6.02) - -
t 1/2 geometric mean (range) (h) OC alone - 33.6 (20.0-78.5) - -
  1 h before exenatide - 32.1 (19.8-55.7) - -
  0.5 h after exenatide - 32.6 (17.9-72.4) - -