Table 1 Ethinyl Estradiol Single- and Multiple-dose Pharmacokinetics: Comparison of Mean Pharmacokinetic Parameters Across Treatments
Single Dose | Multiple Dose | ||||
|---|---|---|---|---|---|
LS Geometric Mean | Comparison to OC alone: Ratio (90% CI) | LS Geometric Mean | Comparison to OC alone: Ratio (90% CI) | ||
AUC (pg·h/mL) | OC alone | 718.89 | - | 761.06 | - |
1 h before exenatide | 691.69 | 0.96 (0.91, 1.02) | 716.70 | 0.94 (0.88, 1.01) | |
0.5 h after exenatide | 692.56 | 0.96 (0.91, 1.02) | 734.01 | 0.96 (0.90, 1.04) | |
C max (pg/mL) | OC alone | 72.18 | - | 102.15 | - |
1 h before exenatide | 65.49 | 0.91 (0.83, 0.99) | 87.09 | 0.85 (0.78, 0.93) | |
0.5 h after exenatide | 38.64 | 0.54 (0.49, 0.58) | 56.32 | 0.55 (0.50, 0.60) | |
24-h concentration (pg/mL) | OC alone | 8.27 | - | 14.64 | - |
1 h before exenatide | 8.13 | 0.98 (0.92, 1.05) | 15.03 | 1.03 (0.95, 1.11) | |
0.5 h after exenatide | 10.25 | 1.24 (1.16, 1.33) | 17.52 | 1.20 (1.10, 1.30) | |
T max median (range) (h) | OC alone | - | 1.50 (0.50-2.50) | - | - |
1 h before exenatide | - | 1.50 (0.50-2.00) | - | - | |
0.5 h after exenatide | - | 6.00 (2.00-6.13) | - | - | |
t 1/2 geometric mean (range) (h) | OC alone | - | 19.5 (13.8-32.1) | - | - |
1 h before exenatide | - | 18.9 (14.0-30.1) | - | - | |
0.5 h after exenatide | - | 17.4 (8.78-31.9) | - | - | |