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Table 1 Ethinyl Estradiol Single- and Multiple-dose Pharmacokinetics: Comparison of Mean Pharmacokinetic Parameters Across Treatments

From: Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial

   Single Dose Multiple Dose
   LS Geometric Mean Comparison to OC alone: Ratio (90% CI) LS Geometric Mean Comparison to OC alone: Ratio (90% CI)
AUC (pg·h/mL) OC alone 718.89 - 761.06 -
  1 h before exenatide 691.69 0.96 (0.91, 1.02) 716.70 0.94 (0.88, 1.01)
  0.5 h after exenatide 692.56 0.96 (0.91, 1.02) 734.01 0.96 (0.90, 1.04)
C max (pg/mL) OC alone 72.18 - 102.15 -
  1 h before exenatide 65.49 0.91 (0.83, 0.99) 87.09 0.85 (0.78, 0.93)
  0.5 h after exenatide 38.64 0.54 (0.49, 0.58) 56.32 0.55 (0.50, 0.60)
24-h concentration (pg/mL) OC alone 8.27 - 14.64 -
  1 h before exenatide 8.13 0.98 (0.92, 1.05) 15.03 1.03 (0.95, 1.11)
  0.5 h after exenatide 10.25 1.24 (1.16, 1.33) 17.52 1.20 (1.10, 1.30)
T max median (range) (h) OC alone - 1.50 (0.50-2.50) - -
  1 h before exenatide - 1.50 (0.50-2.00) - -
  0.5 h after exenatide - 6.00 (2.00-6.13) - -
t 1/2 geometric mean (range) (h) OC alone - 19.5 (13.8-32.1) - -
  1 h before exenatide - 18.9 (14.0-30.1) - -
  0.5 h after exenatide - 17.4 (8.78-31.9) - -