Table 4 Generalized Estimating Equation Analysis for Risk Factors Associated with ADR
From: Adverse drug reactions to antiretroviral therapy (ARVs): incidence, type and risk factors in Nigeria
Variables | N (%) | Unadjusted OR | p | Adjusted OR | p |
|---|---|---|---|---|---|
Gender | Â | Â | Â | Â | Â |
   Female | 1706 (64.4) |  |  |  |  |
   Male | 944 (35.6) | 1.11(0.71-1.73) | 0.663 | 0.83 (0.43-1.57) | 0.562 |
Age (years) | Â | Â | Â | Â | Â |
   15-45 | 2120 (85.3) |  |  |  |  |
   > 45 | 364 (14.7) | 0.81(0.48-1.36) | 0.422 | 1.27 (0.59-2.77) | 0.544 |
Regimen | Â | Â | Â | Â | Â |
TDF_based | 46 (1.7) | Â | Â | Â | Â |
AZT_based | 1374 (52.0) | 0.56 (0.18-1.75) | 0.319 | 0.24 (0.07-0.90) | 0.034 |
D4T_based | 1223 (46.3) | 0.33 (0.10-1.03) | 0.057 | 0.18 (0.05-0.64) | 0.009 |
Duration on treatment (months) | Â | Â | Â | Â | Â |
0-6 | 21 (0.79) | Â | Â | Â | Â |
6-12 | 79 (2.98) | 0.54 (0.33-0.89) | 0.02 | 0.38 (0.16-0.91) | 0.03 |
12-24 | 259 (47.5) | 0.25 (0.15-0.41) | < 0.001 | 0.35 (0.16-0.73) | 0.005 |
24-36 | 952 (35.9) | 0.16 (0.08-0.34) | < 0.001 | 0.37 (0.14-0.96) | 0.042 |
CD4 cell count cells/μL |  |  |  |  |  |
< 350 | 950 (44.8) | Â | Â | Â | Â |
> 350 | 1180 (55.2) | 1.08 (0.6-2.0) | 0.791 | 0.93 (0.51-1.70) | 0.816 |