Table 2 Pharmacokinetic Values
From: Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
| PARAMETER | THIAMINE DOSE | ||
|---|---|---|---|
| 100 mg | 500 mg | 1500 mg | |
| AUC0-10 hr (nmol/Liter × hours) | |||
| whole blood | 214 ± 69 | 623 ± 178 | 2046 ± 1222 |
| plasma | 177 ± 62 | 612 ± 257 | 2059 ± 1415 |
| Cmax (nmol/Liter) | |||
| whole blood | 40 ± 11 | 95 ± 27 | 385 ± 188 |
| plasma | 39 ± 13 | 113 ± 42 | 397 ± 250 |
| Tmax (hours) | |||
| whole blood | 3.43 ± 1.69 | 4.14 ± 1.57 | 4.14 ± 0.90 |
| plasma | 3.14 ± 1.05 | 3.18 ± 0.98 | 4.27 ± 1.01 |