BMC Clinical Pharmacology

Table 2 Pharmacokinetic Values

From: Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

PARAMETER	THIAMINE DOSE
	100 mg	500 mg	1500 mg
AUC_{0-10 hr} (nmol/Liter × hours)
whole blood	214 ± 69	623 ± 178	2046 ± 1222
plasma	177 ± 62	612 ± 257	2059 ± 1415
C_max (nmol/Liter)
whole blood	40 ± 11	95 ± 27	385 ± 188
plasma	39 ± 13	113 ± 42	397 ± 250
T_max (hours)
whole blood	3.43 ± 1.69	4.14 ± 1.57	4.14 ± 0.90
plasma	3.14 ± 1.05	3.18 ± 0.98	4.27 ± 1.01

All values are presented as mean ± standard deviation. p < 0.05 for all pairwise comparisons (plasma and whole blood values were analyzed separately)

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