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Table 5 Effect of Each Initial Treatment Course on Renal Function

From: Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts

 

Indomethacin

Ibuprofen

Comparison between treatments on changes from baseline (ANOVA)

 

Baseline

1st course

p value for change with indomethacin (t-test)

Baseline

1st course

p value for change with ibuprofen (t-test)

p value for main treatment effect

p value for treatment - time interaction

Urine output (mL/kg/hr; mean ± SD)

3.9 ± 1.4

3.6 ± 1.4

0.033 *

4.2 ± 1.6

4.0 ± 1.4

0.24

0.51

0.50

Serum Creatinine (mg/dL; mean + SD)

0.96 ± 0.21

1.06 ± 0.24

<0.001*

0.93 ± 0.2

0.98 ± 0.24

0.005 *

0.039*

0.047 *

  1. Supplemental analyses of the effect of each initial treatment course on renal function.
  2. * denotes statistically significant (p < 0.05) change from baseline within a treatment group
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BMC Clinical Pharmacology

ISSN: 1472-6904