| Indomethacin | Ibuprofen |  |
---|---|---|---|
 | (N = 161) | (N = 182) | p value |
Day of Life at Start of Treatment (mean, SD) | 3.3 ± 2.3 | 3.5 ± 2.7 | NS |
PDA Closed, n (%) | 109 (68) | 129 (71) | 0.4 |
PDA Ligation, n (%) | 45 (28) | 38 (21) | 0.1 |
BPD, n (%) | 72 (45) | 90 (49) | 0.2 |
NEC-related conditions, any, n (%) | 27 (17) | 32 (18) | 0.8 |
NEC, n (%) | 6 (4) | 15 (8) | 0.08 |
   NEC-Like Illness (%) | 13 (8) | 5 (3) | 0.03* |
   Spontaneous Intestinal Perforations, n (%) | 8 (5) | 12 (7) | 0.5 |
ROP, n (%) | 65 (52) | 41 (30) | <0.001* |
Severe ROP: Grades III-V | 15 (12) | 15 (11) | 0.8 |
IVH, any, n (%) | 58 (36) | 57 (31) | 0.4 |
Severe IVH: Grade III/IV | 12 (8) | 12 (9) | 0.6 |
PVL | 4 (2.4) | 3 (1.6) | 0.4 |
Death, n (%) | 12 (7) | 16 (9) | 0.4 |