Table 2 Geometric means (68% inter-percentile range) of the main pharmacokinetic variables for roflumilast and roflumilast N-oxide at steady state
| Â | Regimen A | Regimen B | |
|---|---|---|---|
| Â | Day 11 (roflumilast alone) (n = 12) | Day 18 (roflumilast plus formoterol) (n = 12) | Day 18 (formoterol plus roflumilast) (n = 12) |
Roflumilast | Â | Â | Â |
C trough (μg/L) | 0.53 (0.33-0.85) | 0.50 (0.29-0.86) | 0.37 (0.18-0.77) |
Cmax (μg/L) | 6.89 (4.94-9.62) | 6.43 (4.79-8.63) | 5.92 (4.27-8.22) |
AUCτ (μg.h/L) | 35.8 (27.8-46.1) | 36.9 (28.1-48.4) | 31.8 (21.2-47.7) |
CL/F (L/h) | 13.9 (10.8-17.9) | 13.5 (10.3-17.7) | 15.7 (10.4-23.5) |
Roflumilast N-oxide | Â | Â | Â |
C trough (μg/L) | 12.43 (8.24-18.76) | 12.72 (8.18-19.79) | 10.66 (6.29-18.06) |
AUCτ (μg.h/L) | 417 (299-582) | 414 (293-584) | 369 (254-537) |
Cmax (μg/L) | 23.3 (17.3-31.3) | 23.7 (17.2-32.6) | 22.04 (15.9-30.5) |