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Table 2 Incidence of adverse events

From: Use, tolerability and compliance of spironolactone in the treatment of heart failure

 

Spironolactone users

Spironolactone non-users

Hyperkalemia

408/12,344

(3.3%)

955/69,674

(1.4%)*

Breast complications in men

158/6,368

(2.5%)

380/32,764

(1.2%)*

Breast hypertrophy in men (gynecomastia)

117/6,368

(1.8%)

233/32,764

(0.7%)*

  1. * p < 0.001 (Pearson's chi square test)