Skip to main content

Table 6 AEs reported in >1 subject with normal renal function and varying degrees of renal impairment

From: Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies

   Degree of renal impairment
Adverse event, n (%) Normal renal function (n = 18) Mild (n = 12) Moderate (n = 9) Severe (n = 9)
Any AE 14 (78) 7 (58) 8 (89) 7 (78)
Headache 14 (78) 6 (50) 5 (56) 4 (44)
Nasopharyngitis 1 (6) 1 (8) 2 (22) 0
Fatigue 0 1 (8) 1 (11) 2 (22)
Somnolence 2 (11) 1 (8) 0 0
Nausea 1 (6) 1 (8) 0 1 (11)
Neck pain 0 2 (17) 0 0
Back pain 1 (6) 1 (8) 0 0
Dizziness 0 0 2 (22) 0
Dyspepsia 1 (6) 0 0 1 (11)