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Table 5 AEs reported in >1 subject with normal hepatic function and varying degrees of hepatic impairment

From: Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies

  

Degree of hepatic impairment

Adverse event, n (%)

Normal hepatic function (n = 8)

Mild (n = 8)

Moderate (n = 8)

Severe (n = 8)

Any AE

1 (13)

1 (13)

3 (38)

4 (50)

Headache

1 (13)

1 (13)

2 (25)

3 (38)

Vomiting

1 (13)

0

0

1 (13)