From: Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies
Degree of hepatic impairment
Adverse event, n (%)
Normal hepatic function (n = 8)
Mild (n = 8)
Moderate (n = 8)
Severe (n = 8)
Any AE
1 (13)
3 (38)
4 (50)
Headache
2 (25)
Vomiting
0