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Table 5 AEs reported in >1 subject with normal hepatic function and varying degrees of hepatic impairment

From: Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies

   Degree of hepatic impairment
Adverse event, n (%) Normal hepatic function (n = 8) Mild (n = 8) Moderate (n = 8) Severe (n = 8)
Any AE 1 (13) 1 (13) 3 (38) 4 (50)
Headache 1 (13) 1 (13) 2 (25) 3 (38)
Vomiting 1 (13) 0 0 1 (13)