Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies

Table 1 Child-Pugh classification of hepatic impairment

	Points scored for observed findings
	1 point	2 points	3 points
Encephalopathy grade*	Absent	1 or 2	3 or 4
Ascites	Absent	Slight	Moderate
Serum bilirubin (μmol/L)	<34.2	34.2-51.3	>51.3
Serum albumin (g/L)	>35	28-35	<28
Prothrombin time (INR)	<1.16	1.16-1.56	>1.56
Classification
Child-Pugh grade	Child-Pugh A	Child-Pugh B	Child-Pugh C
Points required	5-6	7-9	10-15

INR, international normalized ratio. *Encephalopathy: Grade 0: normal consciousness, personality, neurological examination, electroencephalogram. Grade 1: restless, sleep disturbed, irritable/agitated, tremor, impaired handwriting, 5 cps waves. Grade 2: lethargic, time disorientated, inappropriate, asterixis, ataxia, slow triphasic waves. Grade 3: somnolent, stuporous, place disorientated, hyperactive reflexes, rigidity, slower waves. Grade 4: unrousable coma, no personality/behaviour, decerebrate, slow 2-3 cps delta activity.