Figure 1From: Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies Zibotentan plasma concentration-time curves. Zibotentan plasma concentration-time curves for (a) subjects with normal hepatic function and varying degrees of hepatic impairment and (b) subjects with normal renal function and varying degrees of renal impairment.Back to article page