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Table 2 Risk for hyperkalemia* with use of commonly used oral contraceptives

From: The association between drospirenone and hyperkalemia: a comparative-safety study

 

Crude HR (95% CI)

Adjusted HR† (95%CI)

Levonorgestrel

1.0 (reference)

1.0

Desogestrel

0.93 (0.79-1.09)

1.00 (0.85-1.17)

Drospirenone

1.26 (1.10-1.44)

1.10 (0.95-1.26)

Ethynodiol diacetate

0.96 (0.67-1.38)

0.71 (0.49-1.02)

Norethindrone acetate

1.41 (1.18-1.68)

1.08 (0.91-1.29)

Norethindrone

1.27 (1.11-1.47)

1.15 (1.00-1.33)

Norgestimate

1.13 (0.98-1.29)

1.27 (1.11-1.46)

Norgestrel

1.13 (0.85-1.49)

1.00 (0.76-1.33)

  1. *Hyperkalemia determined from a diagnostic ICD-9 code (276.7)
  2. † Adjusted by age, calendar time, chronic kidney disease, diabetes mellitus, hypertension, inflammatory bowel disease, obesity, polycystic ovary syndrome, premenstrual tension syndrome (premenstrual syndrome and premenstrual dysphoric disorder), smoking status, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, non-steroidal anti-inflammatory drugs, spironolactone, and other medications known to cause hyperkalemia (cyclosporine, diuretics, heparin, penicillin G, tacrolimus, and trimethoprim).
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BMC Clinical Pharmacology

ISSN: 1472-6904