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Table 1 Characteristics of women included in the study cohort by type of progestin oral contraceptive used (n = 1,148,183)

From: The association between drospirenone and hyperkalemia: a comparative-safety study

  Desogestrel Drospirenone Ethynodiol Diacetate Levonorgestrel Norethindrone Acetate Norethindrone Norgestimate Norgestrel
Number of patients 139,871 224,408 17,295 180,720 93,818 234,105 228,276 29,690
Age 28.7 29.0 28.8 29.0 30.5 29.7 26.9 29.7
Mean follow up (days) 327 272 327 304 240 230 307 249
Number of cases 267 488 33 349 200 433 499 56
Covariates (%)         
   CKD † 0.15 0.09 0.08 0.09 0.12 0.15 0.08 0.19
   Diabetes 4.10 4.10 4.41 3.93 4.13 4.12 3.37 5.43
   Hypertension 8.34 8.47 8.53 8.62 9.78 8.89 6.55 10.82
   IBD* 0.94 1.03 1.22 1.00 1.03 0.85 0.75 0.98
   Obesity 11.59 12.53 12.44 11.22 10.75 10.08 9.50 13.60
PCOS □ 4.47 5.78 5.00 2.11 2.80 2.81 2.21 3.48
   PTS (PMS/PMDD) ‡ 3.63 5.53 3.04 3.01 3.26 1.95 1.69 2.73
   Smoking 6.62 5.94 8.48 7.36 6.43 6.49 6.97 9.00
   ACEI/ARB § 0.50 0.47 0.56 0.60 0.75 0.67 0.42 0.80
   NSAIDS ʗ 5.67 4.84 5.79 5.56 5.13 5.90 4.77 6.09
   Spironolactone 0.43 0.74 0.84 0.28 0.32 0.19 0.32 0.29
   Other Medications ʒ 0.46 0.36 0.56 0.46 0.37 0.35 0.27 0.44
  1. *Inflammatory bowel disease
  2. † CKD = Chronic Kidney Disease
  3. □ PCOS = Polycystic Ovary Syndrome
  4. ‡ PTS (PMS/PMDD) = premenstrual tension syndrome (premenstrual syndrome and premenstrual dysphoric disorder)
  5. § ACE/ARB = angiotensin-converting enzyme inhibitors/angiotensin receptor blockers
  6. ʗ NSAID = non-steroidal anti-inflammatory drugs
  7. ʒ Other medications = diuretics, heparin, cyclosporine, tacrolimus, trimethoprim, and penicillin G