Table 2 Incidence of anti-panitumumab antibodies
From: Immunogenicity of panitumumab in combination chemotherapy clinical trials
Wild-Type KRAS | Mutant KRAS | All Patients* | ||||
|---|---|---|---|---|---|---|
Either Biacore or ELISA | Bioassay | Either Biacore or ELISA | Bioassay | Either Biacore or ELISA | Bioassay | |
Total Antibody Incidence, n 1 /n 2 (%) | ||||||
20050184 | 6/48 (12.5) | 1/48 (2.1) | 0/37 (0) | 0/37 (0) | 6/93 (6.5) | 1/93 (1.1) |
20060277 | 0/64 (0) | 0/64 (0) | 1/45 (2.2) | 1/45 (2.2) | 1/115 (0.9) | 1/115 (0.9) |
20050181 | 11/288 (3.8) | 0/288 (0) | 9/223 (4.0) | 1/223 (0.4) | 22/559 (3.9) | 1/559 (0.2) |
20050203 (Pmab + OX) | 21/308 (6.8) | 3/308 (1.0) | 10/206 (4.9) | 1/206 (0.5) | 36/558 (6.5) | 4/558 (0.7) |
Pmab + IRI | 17/400 (4.3) | 1/400 (0.3) | 10/305 (3.3) | 2/305 (3.3) | 29/767 (3.8) | 3/767 (0.4) |
Pmab + IRI or OX | 38/708 (5.4) | 4/708 (0.6) | 20/511 (3.9) | 3/511 (0.6) | 65/1325 (4.9) | 7/1325 (0.5) |
Pre-existing Antibody Incidence, n 3 /n 4 (%) | ||||||
20050184 | 4/48 (8.3) | 1/48 (2.1) | 0/37 (0) | 0/37 (0) | 4/93 (4.3) | 1/93 (1.1) |
20060277 | 0/64 (0) | 0/64 (0) | 1/45 (2.2) | 1/45 (2.2) | 1/115 (0.9) | 1/115 (0.9) |
20050181 | 11/252 (4.4) | 0/252 (0) | 7/210 (3.3) | 1/210 (0.5) | 19/506 (3.8) | 1/506 (0.2) |
20050203 (Pmab + OX) | 11/282 (3.9) | 2/282 (0.7) | 7/188 (3.7) | 0/188 (0) | 22/511 (4.3) | 2/511 (0.4) |
Pmab + IRI | 15/364 (4.1) | 1/364 (0.3) | 8/292 (2.7) | 2/292 (0.7) | 24/714 (3.4) | 3/714 (0.4) |
Pmab + IRI or OX | 26/646 (4.0) | 3/646 (0.5) | 15/480 (3.1) | 2/480 (0.4) | 46/1225 (3.8) | 5/1225 (0.4) |
Developing Antibody Incidence, n 5 /n 6 (%) | ||||||
20050184 | 2/37 (5.4) | 0/37 (0) | 0/26 (0) | 0/26 (0) | 2/68 (2.9) | 0/68 (0) |
20060277 | 0/42 (0) | 0/42 (0) | 0/30 (0) | 0/30 (0) | 0/75 (0) | 0/75 (0) |
20050181 | 0/255 (0) | 0/255 (0) | 3/205 (1.5) | 0/205 (0) | 4/501 (0.8) | 0/501 (0) |
20050203 (Pmab + OX) | 10/264 (3.8) | 1/264 (0.4) | 3/178 (1.7) | 1/178 (0.6) | 14/480 (2.9) | 2/480 (0.4) |
Pmab + IRI | 2/334 (0.6) | 0/334 (0) | 3/261 (1.1) | 0/261 (0) | 6/644 (0.9) | 0/644 (0) |
Pmab + IRI or OX | 12/598 (2.0) | 1/598 (0.2) | 6/439 (1.4) | 1/439 (0.2) | 20/1124 (1.8) | 2/1124 (0.2) |