Table 1 Immunogenicity assay characteristics
From: Immunogenicity of panitumumab in combination chemotherapy clinical trials
Drug Tolerance† | ||||
|---|---|---|---|---|
Assay | Assay Sensitivity* | LLRD | Anti-panitumumab | Panitumumab |
ELISA | 10 ng/mL | 60 ng/mL | 60 ng/mL 500 ng/mL | 9 μg/mL 81 μg/mL |
Biacore | 1.8 μg/mL | 1.8 μg/mL | 4 μg/mL 20 μg/mL | 1.9 μg/mL 7.8 μg/mL |
Bioassay | ~62.5 ng/mL | ~125 ng/mL | ~1 μg/mL | ~2.5 μg/mL |