What can we learn from consumer reports on psychiatric adverse drug reactions with antidepressant medication? Experiences from reports to a consumer association

Table 2 Reports and ADRs of antidepressant medication to an open web site according to the system organ class of psychiatric system¹.

Antidepressant ATC code N06A	Reports (N) Total = 442	ADRs (N) Total = 2392	Psychiatric ADRs (N) Total = 878	ADRs/report	Most common psychiatric ADR (%)
Sertraline^a	116	626	226	5.4	Anxiety 5.9
N06AB06					Sensation of unreality 4.0
					Insomnia 3.0
					Uneasiness/nervousness 2.6
					Irritability, aggressiveness 2.2
					Suicidal behavior 1.9
Citalopram^a	107	570	226	5.3	Anxiety 7.9
N06AB04					Insomnia 3.7
					Sensation of unreality 2.8
					Suicidal behavior 2.5
					Uneasiness/nervousness 2.5
					Depression 2.1
					Irritability, aggressiveness 2.1
Venlafaxine^b	78	505	171	6.5	Anxiety 4.2
N06AX16					Suicidal behavior 3.2
					Uneasiness/nervousness 2.8
					Sensation of unreality 2.8
					Insomnia 2.4
Paroxetine^a	58	327	121	5.6	Anxiety 5.2
N06AB05					Irritability, aggressiveness 3.4
					Suicidal behavior 3.1
					Insomnia 2.3
					Depression 2.1
Mirtazapine^b	34	131	46	3.9	Anxiety 6.9
N06AX11					Insomnia 6.1
					Irritability, aggressiveness 3.1
					Suicidal behavior 2.3
					Uneasiness/nervousness 2.3
Fluoxetine^a	28	120	39	4.3	Anxiety 5.0
N06AB03					Irritability, aggressiveness 2.5
					Suicidal behavior 2.5
					Insomnia 2.5
Escitalopram^a	21	113	49	5.4	Anxiety 7.1
N06AB10					Sensation of unreality 6.2
					Insomnia 5.3
					Depression 3.5
					Irritability, aggressiveness 3.5
					Suicidal behavior 2.7
					Uneasiness/nervousness 2.7

¹According to ATC classification system, the drugs are divided into different groups according to the organ or system on which they act and their chemical, pharmacological and therapeutic properties.
^aSelective serotonin reuptake inhibitor (SSRI)
^bSerotonin-norepinephrine reuptake inhibitor (SNRI)