Skip to main content

Table 4 Association between statin use and outcomes stratified by statin dose

From: Association between statin therapy and outcomes in critically ill patients: a nested cohort study

 

Statin therapy n = 107

Non-statin therapy n = 656

Adjusted odds ratio (aOR)a

95% confidence interval

P-value

Sepsis, no.%

32/107 (29.9)

280/656 (42.7)

0.84

(0.51 - 1.37)

0.49

   Dose < 40 mg

16/47 (34.0)

280/656 (42.7)

1.11

(0.57 - 2.20)

0.74

   Dose ≥ 40 mg

16/60 (25.7)

280/656 (42.7)

0.67

(0.36 - 1.30)

0.22

Severe sepsis, no. %

26/107 (24.3)

207/656 (31.6)

0.87

(0.51 - 1.50)

0.60

   Dose < 40 mg

11/47 (23.4)

207/656 (31.6)

0.88

(0.42 - 1.90)

0.74

   Dose ≥ 40 mg

15/60 (25.0)

207/656 (31.6)

0.85

(0.44 - 1.65)

0.64

ICU LOS, mean ± SD, days

10.2 ± 12.7

11.3 ± 10.6

*

*

0.33

Hospital LOS, mean ± SD, days

67.6 ± 118.1

58.6 ± 81.4

*

*

0.37

MVD, mean ± SD, days

9.0 ± 11.9

10.1 ± 10.3

*

*

0.33

  1. Variables entered initially in the stepwise regression model including age, gender, admission category, APACHE II, history of diabetes, creatinine, platelets, GCS, and chronic cardiac, renal, and respiratory diseases.