An evaluation of ciprofloxacin pharmacokinetics in critically ill patients undergoing continuous veno-venous haemodiafiltration

Table 2 Estimates of pharmacokinetic parameters obtained from multiple ciprofloxacin serum concentrations in a dosage interval using non-compartmental methods

Patient Profile	Dose (mg)	Dosage Interval (hours)	T_1/2 (hrs)	k (hr^-1)	AUC_0-τ* _{(τ = dosage} _interval) (mg.hr/L)	TBC (Dose/AUC) (L/hr)	Vd_ss (L)
1.A	400	12	35.2	0.020	35.4	11.3	524
1.B	400	12	39.4	0.018	38.3	10.4	555
Mean			37.3	0.019	36.8	10.9	539
2.A	200	12	5.15	0.135	15.2	13.2	104
2.B	200	12	13.8	0.050	16.5	12.2	215
2.C	400	12	12.4	0.056	51.8	7.72
Mean			10.5	0.080		11.0	160
3.A	400	12	5.97	0.116	38.9	10.3	79.5
3.B	400	12	7.50	0.092	40.2	10.0	97.3
Mean			6.73	0.104	39.5	10.1	88.4
4.A	400	24	24.7	0.028	129	3.10	111
4.B	400	12	27.2	0.026	81.5	4.91
Mean			25.9	0.027		4.00
5.A	400	12	8.44	0.082	40.4	9.90	107
5.B	400	12	5.77	0.120	37.8	10.6	81.1
5.C	400	12	6.80	0.102	40.9	9.78	88.2
Mean			7.00	0.101	39.7	10.1	92.2
6.A	400	24	14.0	0.050	43.4	9.22	175
6.B	400	12	14.7	0.047	54.0	7.40	151
6.C	400	12	16.5	0.042	49.6	8.06
Mean			15.0	0.046		8.23	163
7.A	400	24	15.1	0.046	50.6	7.91	164
7.B	400	12	10.4	0.067	39.4	10.1	139
Mean			12.7	0.056		9.00	151

* τ taken to be 24 hours for first profile immediately following a change in prescribed dosage interval (profiles 6b and 7b)