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Table 4 Pharmacokinetic parameters for total phenoxodiol infused at a dose of 2 mg/kg/h.

From: Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer

Patient number

Css (μg/ml)

Time to ss (h)

Acc T1/2 (h)

Cl (L/h)

1*

14.74

3.66

0.73

0.06

2*

32.31

4.00

0.80

0.03

4

13.33

2.00

0.40

0.07

5

14.80

2.00

0.40

0.07

6

12.04

2.33

0.47

0.08

Mean ± SD

17.45 ± 8.38

2.78 ± 0.96

0.56 ± 0.19

0.06 ± 0.01

  1. Abbreviations are the same as for table 3. * In patients 1 and 2 the infusion was not continued long enough to reach steady state and the values calculated are therefore underestimates of the valid results.