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Table 3 Pharmacokinetic parameters for free phenoxodiol infused at a dose of 2 mg/kg/h.

From: Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer

 

Css (μg/ml)

Time to ss(h)

Acc T1/2 (h)

Cl (L/h)

1

0.92

0.67

0.13

1.08

2

0.65

1.00

0.20

1.53

4

0.77

1.00

0.20

1.28

5

0.66

1.00

0.20

1.51

6

0.96

0.67

0.13

1.03

Mean ± SD

0.79 ± 0.14

0.87 ± 0.18

0.17 ± 0.04

1.29 ± 0.23

  1. Css is the plasma concentration at steady state. Time to steady state is the time taken to reach Css. Acc T1/2 is the accumulation half-life. Cl is the plasma clearance rate.
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BMC Clinical Pharmacology

ISSN: 1472-6904