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Table 2 Secondary Outcomes

From: Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis - An open clinical trial-

 

weeks

0

4

8

11

24

52

WOMAC total

Ave ± SD

35.53 ± 15.03

39.75 ± 16.69

29.65 ± 20.4

23.4 ± 16.53

27.25 ± 19.68

26.74 ± 18.7

 

% variation

0

11.88

-16.55

-34.14

-23.3

-24.75

 

*: p ‹ 0.05

      

WOMAC pain

Ave ± SD

3.47 ± 1.77

3.5 ± 1.47

2.45 ± 1.7

2.3 ± 1.3

2.4 ± 1.85

2.53 ± 1.43

 

% variation

0

0.95

-29.33

-33.66

-30.78

-27.13

 

*: p ‹ 0.05

      

Pain at rest

Ave ± SD

14.85 ± 12.4

15.15 ± 8.03

14.15 ± 8.25

7.25 ± 7.41

6.85 ± 8.11

6.65 ± 7.74

 

% variation

0

2.02

-4.71

-51.18

-53.87

-55.22

 

*: p ‹ 0.05

      

Pain while walking

Ave ± SD

32.1 ± 12.4

21.9 ± 8.03

18.5 ± 8.25

11.5 ± 7.41

11.8 ± 8.11

11.4 ± 7.74

 

% variation

0

-31.8

-42.5

-64.3

-63.4

-64.5

 

*: p ‹ 0.05

   

*

*

*

  1. The parameters were shown at entry point, 4th, 8th, 11th, 24th, and 52nd weeks. They were provided as absolute levels, percentage of variation with time and statistical significance. The asterisks indicate statistically significant improvement.
  2. There were significant differences in the values between individual follow-up points in the WOMAC scores, but there was no significant difference in the data comparing the baseline and each follow-up. Pain when walking, as initial checks of each visit at our clinic, showed statistical improvement compared to the baseline measurements at 11th, 24th, and 52nd weeks. These values showed remarkable improvement in percentage of variation with time.