Figure 3

Concentration of C2C in Blood. The concentration of C2C in the blood decreased significantly at 8 and 24 weeks. To check the change of type II collagen metabolism, we measured C2C as a degradation marker of type II collagen, as C2C is said to be the only reliable marker of cartilage metabolism. The significant decreasing tendency of C2C is thought to be more objective than those parameters measured with VAS and ROM findings in this study.