Statistic | Formulation | AUC0-t, ng/mL*h | Cmax, ng/mL | AUC0-t adj, ng/mL*h | Cmax adj, ng/mL |
---|---|---|---|---|---|
 |  |  |  | Adjusted for actual dose | |
Least squares geometric mean | A | 293.1 | 39.52 | 317.4 | 42.80 |
 | B | 277.7 | 39.57 | 309.5 | 44.09 |
 | C | 280.1 | 41.43 | 306.1 | 45.26 |
CV% | Â | 12.2 | 16.2 | 12.3 | 16.2 |
Ratio estimate (95% CI) | A/C | 1.05 (0.98, 1.12) | 0.95 (0.88, 1.04) | 1.04 (0.97, 1.11) | 0.95 (0.87, 1.03) |
 | B/C | 0.99 (0.93, 1.06) | 0.96 (0.88, 1.04) | 1.01 (0.95, 1.08) | 0.97 (0.89, 1.06) |
Ratio estimate (95% CI) (corrected for active content) | A/Ca | 0.98 (0.91, 1.04) | 0.89 (0.82, 0.97) | 0.97 (0.91, 1.03) | 0.88 (0.81, 0.96) |
 | B/Cb | 0.96 (0.90, 1.02) | 0.93 (0.85, 1.01) | 0.98 (0.92, 1.05) | 0.94 (0.87, 1.03) |