From: The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol
Ibuprofen | Paracetamol | |||
---|---|---|---|---|
Twice daily | Three times daily | Twice daily | Three times daily | |
n | 26 | 26 | 26 | 26 |
t max , hrs | 1.50a | 1.50a | 0.67a | 0.67a |
C max , μg.mL -1 (sd) | 33.4 (6.12) | 33.55 (7.32) | 16.09 (5.14) | 15.87 (5.26) |
C min , μg,mL -1 (sd) | 0.72 (0.42) | 2.64 (1.24) | 0.74 (0.25) | 1.87 (0.79) |
C av , μg.mL -1 (sd) | 9.61 (1.96) | 13.69 (2.73) | 4.07 (1.05) | 5.86 (1.68) |
Fluctuation (sd) | 3.44 (0.65) | 2.26 (0.50) | 3.83 (1.02) | 2.47 (0.83) |
(C max -C min )/C av | ||||
Swing (sd) (C max -C min )/C min | 62.47 (40.28) | 14.90 (8.72) | 22.81 (10.05) | 8.73 (4.78) |
AUC 0-t , μg.mL -1 .hr (sd) | 230.73 (47.00) | 328.60 (65.71) | 97.67 (25.13) | 140.80 (40.30) |
AUC tau , μg.mL -1 .hr (sd) | 118.12 (24.23) | 114.26 (22.77) | 51.72 (12.89) | 50.74 (13.29) |