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Table 3 Mean derived comparison of the single-dose pharmacokinetic parameters in subjects allocated to the twice or three times daily dosing regimen (Study 2; Day 2)

From: The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol

 

Ibuprofen

Paracetamol

 

Twice daily

Three times daily

Twice daily

Three times daily

n

26

26

26

26

t max , hrs

1.75a

1.25a

0.67a

0.67a

C max , μg.mL -1 (sd)

32.53 (6.15)

36.66 (8.14)

14.74 (5.76)

15.86 (4.76)

AUC 0-t , μg.mL -1 .hr (sd)

128.29 (23.60)

124.01 (23.35)

46.98 (12.42)

47.58 (12.79)

AUC 0-inf , μg.mL -1 .hr (sd)

130.67 (24.61)

132.27 (25.54)

49.23 (12.99)

52.49 (14.06)

  1. AUC0-inf: area under the curve calculated by linear trapezoidal rule to the last measurable plasma concentration (Cp) with additional area calculated from Cp/Kel (elimination rate constant); AUC0-t: area under the curve calculated by linear trapexoidal rule to the last measurable plasma concentration; Cmax: maximum plasma concentration; hr(s): hour(s); tmax: time of maximum plasma concentration; t1/2: plasma concentration half life; sd: standard deviation. aMedian values.
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BMC Clinical Pharmacology

ISSN: 1472-6904