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Table 2 Mean derived pharmacokinetic profiles for ibuprofen and paracetamol after administration of the fixed-dose combination tables in the fed and fasted states (Study 1)

From: The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol

 

Ibuprofen

Paracetamol

 

Fed

Fasted

Fed

Fasted

n

25

25

25

25

t max , hrs

2.00a

1.25a

1.50a

0.50a

Median difference [minutes] fed vs fasted, 95% CI

25.0, 0.0-45.0

55.0, 30.0-80.0

t 1/2 , hrs

2.25

1.95

2.73

2.83

C max , μg.mL -1

24.74

32.04

11.14

18.48

LS geometric mean

24.03

31.46

10.71

17.58

Ratio fed/fasted (%), 90% CI

76.38, 70.25-83.06

60.92, 53.43-69.46

AUC 0-t , μg.mL -1 .hr

103.91

118.32

46.45

51.69

LS geometric mean

101.6 2

116.51

45.69

50.27

Ratio fed/fasted (%), 90% CI

87.22, 84.06-90.49

90.89, 87.38-94.54

AUC 0-inf , μg.mL -1 .hr

109.03

120.92

49.51

54.49

LS geometric mean

106.04

118.82

48.72

52.95

Ratio fed/fasted (%), 90% CI

89.25, 86.14-92.46

92.01, 88.45-95.71

Kel

0.328

0.361

0.258

0.251

  1. AUC0-inf: area under the curve calculated by linear trapezoidal rule to the last measurable plasma concentration (Cp) with additional area calculated from Cp/Kel; AUC0-t: area under the curve calculated by linear trapexoidal rule to the last measurable plasma concentration; Cmax: maximum plasma concentration; Kel: elimination rate constant; tmax: time of maximum plasma concentration; hr(s): hour(s); LS: least square; sd: standard deviation. aMedian values.