Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations

Table 8 Effect of concomitant use of aspirin and NSAIDs among current users as compared to non use of either drug (multiple users of NSAIDs were excluded).

	All cases (UGIB/Perforation)	Controls	Adjusted RR^*
	(N=2,105)	(N=11,500)	(95%CI)
Low-medium-dose NSAIDs only	83(71/12)	256	2.6 (2.0-3.4)
High-dose^# NSAIDs only	254 (202/52)	413	4.3 (3.6-5.2)
Only aspirin	221 (201/20)	767	2.1 (1.8-2.5)
Aspirin + low-medium-dose NSAIDs	9 (6/3)	34	2.2 (1.0-4.6)
Aspirin + high-dose^# NSAIDs	57 (41/16)	36	13.3 (8.5-20.9)

^*Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of anticoagulants, steroids, SSRIs and paracetamol. # High-dose NSAIDs: Aceclofenac > 100, acemetacin > 120, diclofenac > 75, etodolac > 400, fenbufen > 900, fenoprofen > 1200, flurbiprofen > 150, ibuprofen > 1200, indometacin > 75, ketoprofen > 100, mefenamic acid > 1000, tiaprofenic acid > 450, azapropazone > 600, meloxicam > 7.5, nabumetone > 1000, naproxen > 500, piroxicam > 10, sulindac > 200, tenoxicam > 10 (all doses in mg).