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Table 7 Effect of duration of treatment with aspirin on the risk of UGIB and perforation among current users as compared to non-use by aspirin dose

From: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations

 

All cases

Controls

Adjusted RR*

 

(N=2,105)

(N=11,500)

(95%CI)

Daily dose as instructed/

   

Days of treatment/

   

   75 mg

   

1-60

17

32

3.2 (1.7-6.1)

61-180

20

37

2.9 (1.6-5.2)

181-730

53

166

1.7 (1.2-2.5)

>731

51

185

1.7 (1.3-4.6)

   150 mg

   

1-60

13

11

6.6 (2.7-15.9)

61-180

11

23

2.7 (1.2-6.0)

181-730

26

83

2.0 (1.2-3.2)

>730

34

128

1.5 (1.0-2.2)

   300 + mg

   

1-60

10

9

6.0 (2.2-16.2)

61-180

3

11

1.9 (0.5-7.1)

181-730

17

37

2.6 (1.4-4.9)

>730

32

115

1.7 (1.1-2.6)

  1. *Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of NSAIDs, anticoagulants, steroids, SSRIs and paracetamol.