| |
All cases
|
Controls
|
Adjusted RR*
|
|---|
| |
(N=2,105)
|
(N=11,500)
|
(95%CI)
|
|---|
|
Days of treatment
| | | |
|
(consecutive prescriptions)
| | | |
|
1-60 (all users)
|
40
|
52
|
4.5 (2.9-7.1)
|
|
First-ever users
|
25
|
32
|
4.6 (2.7-8.1)
|
|
Distant users
|
15
|
20
|
4.2 (2.0-8.6)
|
|
61-180
|
34
|
71
|
2.7 (1.7-4.2)
|
|
181-730
|
96
|
286
|
1.9 (1.5-2.5)
|
|
>730
|
117
|
428
|
1.6 (1.3-2.0)
|
-
*Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of NSAIDs, anticoagulants, steroids, SSRIs and paracetamol. Additional adjustment for antiulcer drugs use did not change the estimates.
