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Table 6 Effect of duration of treatment with aspirin on the risk of UGIB and perforation among current users as compared to non-use

From: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations

 

All cases

Controls

Adjusted RR*

 

(N=2,105)

(N=11,500)

(95%CI)

Days of treatment

   

(consecutive prescriptions)

   

   1-60 (all users)

40

52

4.5 (2.9-7.1)

First-ever users

25

32

4.6 (2.7-8.1)

Distant users

15

20

4.2 (2.0-8.6)

   61-180

34

71

2.7 (1.7-4.2)

   181-730

96

286

1.9 (1.5-2.5)

   >730

117

428

1.6 (1.3-2.0)

  1. *Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of NSAIDs, anticoagulants, steroids, SSRIs and paracetamol. Additional adjustment for antiulcer drugs use did not change the estimates.