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Table 4 Risk of UGIB and perforation associated with aspirin use according to location, type of lesion and aspirin formulation

From: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations

   Adjusted*RR (95% CI)
   All cases UGIB Perforation
All sites Plain 1.9 (1.6-2.3) 2.0 (1.6-2.4) 1.6 (1.1-2.5)
  Coated 2.3 (1.6-3.2) 2.2 (1.5-3.2) 2.4 (1.1-5.0)
Gastric Plain 2.0 (1.5-2.5) 2.0 (1.6-2.6) - $
  Coated 2.2 (1.4-3.6) 2.3 (1.4-3.8)  
Duodenal Plain 1.6 (1.3-2.1) 1.5 (1.2-2.0) 1.8 (1.1-2.8)
  Coated 2.2 (1.4-3.4) 1.9 (1.1-3.2) 2.9# (1.4-6.1)
  1. * Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of NSAIDs, anticoagulants, steroids, SSRIs and paracetamol $ Only 3 cases of gastric perforation exposed to plain aspirin and none to coated aspirin # Based on 9 exposed cases and 142 controls