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Table 4 Risk of UGIB and perforation associated with aspirin use according to location, type of lesion and aspirin formulation

From: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations

  

Adjusted*RR (95% CI)

  

All cases

UGIB

Perforation

All sites

Plain

1.9 (1.6-2.3)

2.0 (1.6-2.4)

1.6 (1.1-2.5)

 

Coated

2.3 (1.6-3.2)

2.2 (1.5-3.2)

2.4 (1.1-5.0)

Gastric

Plain

2.0 (1.5-2.5)

2.0 (1.6-2.6)

- $

 

Coated

2.2 (1.4-3.6)

2.3 (1.4-3.8)

 

Duodenal

Plain

1.6 (1.3-2.1)

1.5 (1.2-2.0)

1.8 (1.1-2.8)

 

Coated

2.2 (1.4-3.4)

1.9 (1.1-3.2)

2.9# (1.4-6.1)

  1. * Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of NSAIDs, anticoagulants, steroids, SSRIs and paracetamol $ Only 3 cases of gastric perforation exposed to plain aspirin and none to coated aspirin # Based on 9 exposed cases and 142 controls