Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people

Table 2 Reasons for withdrawal of patients in the run-in period who attended their Randomisation appointment

Reason	Overall
Cancer diagnosed during run-in	28
MI, stroke or hospitalisation for angina during run-in	94
Lipid-lowering drug started	271
New unexplained muscle symptoms	531
Other adverse event	161
Patient wishes or long-term adherence in doubt	2992
Patient's physician discouraged participation	25
Other reasons	135
Any of the above	3438