Table 1 Rawlins' classification system of ADRs

A

Dose-dependent ADRs related to the pharmacological effect of the drug:

   • Increased pharmacological effect

   • ADRs that occur secondarily to the desired pharmacological effect

   • ADRs due to other well known pharmacological effects

B

Sensitivity reactions – not dose-dependent

   • Allergic reactions

   • Idiosyncratic reaction

C

Long-term ADRs

   • Carcinogines

   • Teratogenes

   • Chronic organ damage

D

Drug-drug interactions

   • Pharmacodynamic

   • Pharmacokinetic

   • Non-classifiable