Table 2 Pharmacokinetic parameters by treatment and dose level
Treatment | Dose | N | Cmax | AUC(0–72) | AUC(0-∞) | Clearance | Terminal elimination half life | Estimated Alpha half life | Volume of distribution | Volume of distribution | Tmax* |
|---|---|---|---|---|---|---|---|---|---|---|---|
mcg/kg | pg/mL | hr*pg/mL | hr*pg/mL | mL/min | hr | hr | L | L/kg | hr | ||
AVI-014 | 4 | 16 | 16,944 (5,804) | 138,993 (48,262) | 139,818 (48,332) | 43 (18) | 15.1 (3.6) | 3.4 (0.5) | 58 (33) | 0.73 (0.37) | 4.5 |
Filgrastim | 4 | 8 | 22,595 (6,076) | 175,323 (50,665) | 176,145 (51,004) | 32 (8) | 14.7 (3.9) | 2.8 (0.6) | 42 (19) | 0.54 (0.27) | 5 |
AVI-014 | 8 | 8 | 31,460 (7,927) | 312,569 (81,029) | 313,525 (81,043) | 35 (11) | 11.0 (2.2) | 3.7 (0.3) | 35 (18) | 0.45 (0.23) | 5 |
Filgrastim | 8 | 8 | 41,442 (9,986) | 347,053 (70,749) | 347,489 (70,698) | 36 (10) | 9.8 (2.3) | 3.1 (0.5) | 31 (15) | 0.35 (0.14) | 6 |