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Table 2 Selegiline and Metabolites Excreted in the 24 Hour Urines from 0–24, 24–48, and 48–72 hours After Cocaine (Mean ± SD, N = 12)

From: A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion

Drug Assayed

0–24 hours

(day 11)

24–48 hours

(day 12)

Statistical p Value

0–24 vs. 24–48 hours

48–72 hours

(day 13)

Selegiline

0.109 ± 0.073

0.145 ± 0.138

0.34

0.063 ± 0.097

Desmethylselegiline

0.184 ± 0.128

0.188 ± 0.162

0.75

0.082 ± 0.086

l-Methamphetamine

6.26 ± 2.28

8.51 ± 5.69

0.20

4.83 ± 1.55

l-Amphetamine

2.34 ± 0.85

3.30 ± 2.34

0.18

2.15 ± 0.94

  1. Infusion started on Day 11 at 11 AM, 2 hr after the 9 AM daily patch application.
  2. No selegiline daily patch was applied at 9 AM on day 14.
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BMC Clinical Pharmacology

ISSN: 1472-6904