Table 1 50% Inhibitory concentrations IC50 (nM) of ZL3 B, bortezomib, chloroquine and pyrimethamine in P. falciparum strains
From: Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B
3D7 | HB3 | W2 | Dd2 | |
|---|---|---|---|---|
ZL 3 B | 40 ± 12 | 45 ± 5.8 | 34 ± 3.9 | 40 ± 11.1 |
Bortezomib | 31 ± 1.8 | 31 ± 2.7 | 43 ± 4 | 37 ± 5.1 |
Chloroquine | 6 ± 0.2 | 8 ± 1.4 | 90 ± 3.7 | 300 ± 21 |
Pyrimethamine | 5 ± 1.1 | 500 ± 45 | 1500 ± 5.8 | 2500 ± 97 |