Figure 1
From: Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B
Structures of ZL3B (A) and bortezomib (B). Inhibition of 3D7 (closed squares), HB3 (open squares), W2 (open circles), and Dd2 (open triangles) parasite clones as a function of ZL3B (C), bortezomib (D), pyrimethamine (E) and chloroquine (F) concentrations. The clones of P. falciparum used in this study were obtained from the Malaria Research and Reference Reagent Resource Center (MR4). IC50's are represented in nM. Values are means ± standard deviation of three independent experiments each performed in triplicate.