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Table 6 PK parameters of nicotine in plasma after swallowing without sucking of increasing numbers of 1 mg lozenge (mean ± SD; n = 8 per group)

From: Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell®)

Group\PK parameter

A

B

C

 

3 lozenges

6 lozenges

12 lozenges

C max (ng/ml)

8.2 ± 7.6

16.9 ± 11.8

20.5 ± 8.8

t max (h)

2.7 ± 2.8

2.8 ± 2.0

2.2 ± 1.4

AUC 10 min-12 h (h.ng/ml)

37.0 ± 27.2

84.9 ± 48.9

103.1 ± 58.6

  1. PK parameters were not corrected for baseline plasma nicotine levels.
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BMC Clinical Pharmacology

ISSN: 1472-6904