Formulation\PK parameter | Nicotinell® lozenge | Nicorette® gum | |
---|---|---|---|
1 mg | 2 mg | 2 mg | |
Amount of nicotine released after 30 min (mg) [% of minimal content] | 0.67 ± 0.14 [67%] | 1.39 ± 0.28 [67%] | 0.81 ± 0.25 [42%] |
observed C max (ng/ml) [adjusted]†‡ | 2.3 ± 0.8 [3.5 ± 1.1]† | 4.8 ± 1.4 [7.0 ± 1.7] | 2.9 ± 1.2 |
t max (h) [median (range)] | 1.1 ± 0.7 [0.8 (0.8–3.0)] | 0.8 ± 0.2 [0.8 (0.6–1.1)] | 0.8 ± 0.1 [0.8 (0.5–1.0)] |
t 1/2 (h) | 2.7 ± 0.7 | 2.8 ± 0.7 | 2.5 ± 1.0 |
AUC 0-t (h·ng/ml) | 8.3 ± 2.5 | 15.8 ± 4.1 | 10.6 ± 4.4 |
observed AUC 0–∞ (h·ng/ml) [adjusted]†‡ | 10.7 ± 3.1 [16.5 ± 4.6] | 20.0 ± 5.9 [30.1 ± 9.7] | 13.8 ± 5.6 |