From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
Subject | Clint_L (l/min) | Clint_K (l/min) | Fraction to ramiprilat | IV Ramipril Ave. Error | Oral Ramipril Ave. Error |
---|---|---|---|---|---|
1 | 4.8 | 1.2 | 0.1 | 0.2 | 0.23 |
3 | 1 | 1.5 | 0.32 | 0.17 | 0.25 |
4 | 3.6 | 0.9 | 0.4 | 0.23 | 0.27 |
5 | 2 | 2 | 0.0 | 0.17 | Poor fit |
6 | 3 | 1 | 0.25 | 0.23 | 0.28 |
7 | 4 | 1 | 0.2 | 0.14 | 0.14 |
8 | 5.5 | 0 | 0.4 | 0.13 | 0.22 |
9 | 3.48 | 0.52 | 0.2 | 0.12 | 0.38 |
10 | 3.5 | 1.5 | 0.4 | 0.30 | 0.34 |
11 | 2.8 | 1.2 | 0.3 | 0.23 | 0.14 |
12 | 6.16 | 0.84 | 0.2 | 0.13 | 0.2 |
Ave (SD) | 3.62 (1.5) | 1.06 (0.53) | 0.25 (0.13) | 0.19 (0.057) | 0.24 (0.077) |